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Matthew Ferguson, Ph.D.

Matt Ferguson, Physics, studio portraitAssistant Professor, Department of Physics

Mailing Address:
Boise State University
Department of Physics
1910 University Drive
Boise, ID 83725-1570

Office Location: Multipurpose Classroom Building, 416
Lab Location: Multipurpose Classroom Building, 308W
Office Phone Number: 208-426-3722
Lab Phone Number: 208-426-3797
Office Fax: 208-426-4330
E-Mail Address:
Ferguson Lab website




• PHYS 436/536 Soft Matter (Spring 2014)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2014)
PHYS 436/536 Soft Matter (Spring 2015)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2015)
• PHYS 301 Analog & Digital Electronics (Spring 2016)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2016)
• PHYS 301 Analog & Digital Electronics (Spring 2017)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2017)
• PHYS 301 Analog & Digital Electronics (Spring 2018)
BMOL 603 Biophysical Instrumentation and Techniques (Fall 2018)
PHYS 301 Analog & Digital Electronics (Spring 2019)


Following two post-doctoral fellowships studying experimental biophysics at the Centre de Biochimie Structurale, in Montpellier, France, and at the National Institutes of Health, in Bethesda, MD, Dr. Matthew Ferguson joined the faculty of the Department of Physics at Boise State University in late 2013. He earned his doctorate in physics from the University of Maryland and his bachelors of science in physics & mathematics from Texas Christian University in Fort Worth. He is a tribal member of the Choctaw Nation of Oklahoma and a descendent of Tushpa “John Culberson”.

Dr. Ferguson’s current research focus is on understanding the physical basis of transcriptional regulation and splicing of RNA in eukaryotes by single molecule live cell fluorescence microscopy.  He is an experimental biophysicist. An underlying theme in his research has been the interface between dynamical systems and thermodynamics in both physical and biological systems. Through the combination of physics, computer simulation and multidimensional data analysis, he interprets the results of experiments in a straightforward way, turning information into knowledge about a physical or biological system.


Google Scholar

Stavreva DA, Garcia DA, Fettweis G, Gudla PR, Zaki G, Soni V, McGowanA, Williams G, Huynh A, Palangat M, Schiltz RL, Johnson TA, Ferguson ML, Pegoraro G, Larson DR, Upadhyaya A, Hager GL, Transcriptional bursting and co-bursting regulation by steroid hormone release pattern and transcription factor mobility. Molecular Cell. 2019(in press).

Donovan BT, Huynh A, Ball DB, Poirier MG, Larson DR, Ferguson ML*, Lenstra TL*, Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting. EMBO Journal. 2019.(preprint)

Panchapakesan SSS, Ferguson ML, Hayden EJ, Chen X, Hoskins AA, Unrau PJ. Ribonucleoprotein Purification and Characterization using RNA Mango. RNA. 2017

Coulon* A, Ferguson* ML, de Turris V, Palangat M, Chow CC, Larson DR. Kinetic competition during the transcription cycle results in stochastic RNA processing. eLife. 2014 (*authors contributed equally)

Moutin E, Compan V, Raynaud F, Clerte C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J. The stoichiometry of scaffold complexes in living neurons-DLC2 functions as a dimerization engine for GKAP. Journal of Cell Science. 2014

Ferguson ML, Le Coq D, Jules M, Aymerich S, Radulescu O, Declerck N, et al. Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states. Proc Natl Acad Sci U S A. 2012.

Ferguson ML, Le Coq D, Jules M, Aymerich S, Declerck N, Royer CA. Absolute quantification of gene expression in individual bacterial cells using two-photon fluctuation microscopy. Anal Biochem. 2011.

Savatier J, Jalaguier S, Ferguson ML, Cavailles V, Royer CA. Estrogen receptor interactions and dynamics monitored in live cells by fluorescence cross-correlation spectroscopy. Biochemistry. 2010.

Chaix D, Ferguson ML, Atmanene C, Van Dorsselaer A, Sanglier-Cianferani S, Royer CA, et al. Physical basis of the inducer-dependent cooperativity of the Central glycolytic genes Repressor/DNA complex. Nucleic Acids Res. 2010

Ferguson ML, Prasad K, Boukari H, Sackett DL, Krueger S, Lafer EM, et al. Clathrin triskelia show evidence of molecular flexibility. Biophys J. 2008.

Ferguson ML, Prasad K, Sackett DL, Boukari H, Lafer EM, Nossal R. Conformation of a clathrin triskelion in solution. Biochemistry. 2006.

Pomerance A, Matthews J, Ferguson M, Urbach JS, Losert W. Actin polymerization in a thermal gradient. Macromol Symp. 2005

Ferguson ML, Miller BN, Thompson MA. Dynamics of a gravitational billiard with a hyperbolic lower boundary. Chaos. 1999.

Sieminska L, Ferguson M, Zerda TW, Couch E. Diffusion of steroids in porous sol-gel glass: Application in slow drug delivery. J Sol-Gel Sci Techn. 1997.


Ferguson ML, Larson DR. Measuring Transcription Dynamics in Living Cells using Fluctuation Analysis. Methods in Molecular Biology 2013.