Boise State University
Department of Physics
1910 University Drive
Boise, ID 83725-1570
Office Location: Multipurpose Classroom Building, 416
Lab Location: Multipurpose Classroom Building, 308W
Office Phone Number: 208-426-3722
Lab Phone Number: 208-426-3797
Office Fax: 208-426-4330
E-Mail Address: firstname.lastname@example.org
Ferguson Lab website
- Ph.D. Physics, University of Maryland College Park, 2007
- M.S. Physics, University of Maryland College Park, 2002
- B.S. Physics and Mathematics, Texas Christian University, 1997
- 2017 12th LFD Workshop: Laboratory for Fluorescence Dynamics, Irvine, CA
- 2012 GENEX: Course on Eukaryotic Gene Expression, Cold Spring Harbor Laboratory, NY
- 2011-2013 National Cancer Institute Postdoctoral Fellow, Systems Biology of Gene Expression, Bethesda, MD (w/ Daniel R. Larson)
- 2007 BIOSAS: Course on Biomacromolecules in Solution Studied by Small-Angle Scattering, Copenhagen DK
- 2007-2011 NSF/EMBO/Marie Currie Postdoctoral Fellow, Centre de Biochimie Structurale, Montpellier, FR (w/ Catherine A. Royer)
- 2003-2007 Graduate Partnership Program, National Institutes of Child Health and Human Development, Bethesda, MD (w/ Ralph J. Nossal)
- 2001 NSF Summer School on Nonequilibrium Statistical Physics, Boulder CO
- 1997-1999 Operations Research Analyst, Lockheed Martin Tactical Aircraft Systems, Fort Worth, TX
• PHYS 436/536 Soft Matter (Spring 2014)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2014)
• PHYS 436/536 Soft Matter (Spring 2015)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2015)
• PHYS 301 Analog & Digital Electronics (Spring 2016)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2016)
• PHYS 301 Analog & Digital Electronics (Spring 2017)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2017)
• PHYS 301 Analog & Digital Electronics (Spring 2018)
• BMOL 603 Biophysical Instrumentation and Techniques (Fall 2018)
• PHYS 301 Analog & Digital Electronics (Spring 2019)
Following two post-doctoral fellowships studying experimental biophysics at the Centre de Biochimie Structurale, in Montpellier, France, and at the National Institutes of Health, in Bethesda, MD, Dr. Matthew Ferguson joined the faculty of the Department of Physics at Boise State University in late 2013. He earned his doctorate in physics from the University of Maryland and his bachelors of science in physics & mathematics from Texas Christian University in Fort Worth. He is a tribal member of the Choctaw Nation of Oklahoma and a descendent of Tushpa “John Culberson”.
Dr. Ferguson’s current research focus is on understanding the physical basis of transcriptional regulation and splicing of RNA in eukaryotes by single molecule live cell fluorescence microscopy. He is an experimental biophysicist. An underlying theme in his research has been the interface between dynamical systems and thermodynamics in both physical and biological systems. Through the combination of physics, computer simulation and multidimensional data analysis, he interprets the results of experiments in a straightforward way, turning information into knowledge about a physical or biological system.
Stavreva DA, Garcia DA, Fettweis G, Gudla PR, Zaki G, Soni V, McGowanA, Williams G, Huynh A, Palangat M, Schiltz RL, Johnson TA, Ferguson ML, Pegoraro G, Larson DR, Upadhyaya A, Hager GL, Transcriptional bursting and co-bursting regulation by steroid hormone release pattern and transcription factor mobility. Molecular Cell. 2019(in press).
Donovan BT, Huynh A, Ball DB, Poirier MG, Larson DR, Ferguson ML*, Lenstra TL*, Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting. EMBO Journal. 2019.(preprint)
Panchapakesan SSS, Ferguson ML, Hayden EJ, Chen X, Hoskins AA, Unrau PJ. Ribonucleoprotein Purification and Characterization using RNA Mango. RNA. 2017
Coulon* A, Ferguson* ML, de Turris V, Palangat M, Chow CC, Larson DR. Kinetic competition during the transcription cycle results in stochastic RNA processing. eLife. 2014 (*authors contributed equally)
Moutin E, Compan V, Raynaud F, Clerte C, Bouquier N, Labesse G, Ferguson ML, Fagni L, Royer CA, Perroy J. The stoichiometry of scaffold complexes in living neurons-DLC2 functions as a dimerization engine for GKAP. Journal of Cell Science. 2014
Ferguson ML, Le Coq D, Jules M, Aymerich S, Radulescu O, Declerck N, et al. Reconciling molecular regulatory mechanisms with noise patterns of bacterial metabolic promoters in induced and repressed states. Proc Natl Acad Sci U S A. 2012.
Ferguson ML, Le Coq D, Jules M, Aymerich S, Declerck N, Royer CA. Absolute quantification of gene expression in individual bacterial cells using two-photon fluctuation microscopy. Anal Biochem. 2011.
Savatier J, Jalaguier S, Ferguson ML, Cavailles V, Royer CA. Estrogen receptor interactions and dynamics monitored in live cells by fluorescence cross-correlation spectroscopy. Biochemistry. 2010.
Chaix D, Ferguson ML, Atmanene C, Van Dorsselaer A, Sanglier-Cianferani S, Royer CA, et al. Physical basis of the inducer-dependent cooperativity of the Central glycolytic genes Repressor/DNA complex. Nucleic Acids Res. 2010
Ferguson ML, Prasad K, Boukari H, Sackett DL, Krueger S, Lafer EM, et al. Clathrin triskelia show evidence of molecular flexibility. Biophys J. 2008.
Ferguson ML, Prasad K, Sackett DL, Boukari H, Lafer EM, Nossal R. Conformation of a clathrin triskelion in solution. Biochemistry. 2006.
Pomerance A, Matthews J, Ferguson M, Urbach JS, Losert W. Actin polymerization in a thermal gradient. Macromol Symp. 2005
Ferguson ML, Miller BN, Thompson MA. Dynamics of a gravitational billiard with a hyperbolic lower boundary. Chaos. 1999.
Sieminska L, Ferguson M, Zerda TW, Couch E. Diffusion of steroids in porous sol-gel glass: Application in slow drug delivery. J Sol-Gel Sci Techn. 1997.
CONTRIBUTIONS TO BOOKS
Ferguson ML, Larson DR. Measuring Transcription Dynamics in Living Cells using Fluctuation Analysis. Methods in Molecular Biology 2013.
Boise State Biophysicist Awarded NIH Grant to Study How the Genome Works
Ph.D. in Biomolecular Sciences
Boise State Physicist Extracts Lessons from Sea Squirts
When Timing Matters
Microscope reveals a little splice of life
Finding Order in Randomness: Single-Molecule Studies Reveal Stochastic RNA Processing